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Abstract Detail


Economic Botany Section

Mohd, Rasheeduddin [1], Abdullah Al-Harbi, Naif [2], Gunasekaran, M [3], Nooruddin, Thajuddin [4].

Effect of Medicinal plants on Moraxella cattarhalis..

Background: The emergence of Moraxella catarrhalis as a pathogen in the last decade, together, with increasing prevalence of beta-lactamase producing strains, has renewed interest in these bacterial species. Resistance to conventional antimicrobial agents is rising worldwide, it is necessary to have alternative agents available. The objective of this study was to determine the antimoraxella activity of Ethiopian medicinal plants extracts.Methods: Two clinical isolates of M. cattarhalis with different antibiotic sensitivity pattern were tested to determine their susceptibility to garlic (Ailiurn sativum), bark of cinnamon (Cinnamornum zeylanicum), clove (Syzygium aromas/cum), and leaves of avocado (Persea americana), rosemary (Rosmarinus officinalis) and prickly poppy (Argemone mexicana). Disk diffusion assay and broth dilution method were used to measure one of inhibition, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (103C) of plant extracts against M cattarhalis.Results: Both the strains of M cattaritalis exhibited similar sensitivities to the extracts of medicinal plants. Antimoraxella activity was exhibited only by garlic, avocado leaves and cinnamon. Garlic was found to be more antagonistic to M. cattarhalis than cinnamon and avocado. Garlic and avocado leaves have shown similar MIC (30 mgimi) where as their zone of inhibition (15 and 11 mm, respectively) were different. Conclusion: Garlic, cinnamon and avocado leaves extracts represents alternative source of natural antimicrobial substances for use in clinical practice for the treatment of cases of liticatiarhalis.Further research on the effects of these extracts on M cattarhalis can be rewarding to pursue in the search for new broad spectrum antimicrobial agents.Keywords: Mora:cella catarrhal's, minimum inhibitory concentration, minimum bactericidal concentration

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1 - Haramaya University, Haramaya, Haramaya, 1230567, Ethiopia
2 - King Saud University, Botany and Microbiology, Riyadh, Riyaud, 11451, Saudi Arabia
3 - Fisk University, Biology, 1000 17th Ave North, Nashville, TN, 37208, USA
4 - Bharathidasan University, Microbiology, Tiruchirappalli, Tamilnadu, 620024, India

Keywords:
Moraxella catarrhallis
MIC
Bacteria
bactericidal.

Presentation Type: Poster:Posters for Sections
Session: P
Location: Battelle South/Convention Center
Date: Monday, July 9th, 2012
Time: 5:30 PM
Number: PEN005
Abstract ID:168


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