Economic Botany Section
Adongbede , Erute Magdalene , Egboduku, Wisdom .O. .
Screening of some Nigerian Medicinal Plants for Anti-candida Activity.
The incidence and severity of candidiasis in West Africa is quite high particularly among HIV positive patients. Candida albicans has become resistant to the commonly used anti-candida agents. These drugs are quite often expensive and in limited quantities and also with undesirable adverse effects. These factors necessitate the need to search for new antifungal agents. One hundred and five extracts of twenty one Nigerian medicinal plants obtained through literature and interviews with traditional medical practitioners were evaluated for anti-candida activity. Aqueous, methanol, ethanol, n-hexane and chloroform extracts were screened for anti-candida activity by the disc well diffusion method using Candida albicans and Candida krusei. Fourteen of the plants showed anti-candida activity i.e. 66.67% with the ethanol extract, and 33.33%, 52.38%, 9.52% for the methanol, n-hexane, chloroform respectively and none recorded significant activity with the aqueous extract. The effect of the plant extract on Candida krusei was less as only 38.00% of the plants showed activity for ethanol, 33.33%, 19.04%, 4.76% for methanol, n-hexane, chloroform respectively and little or no activity for the aqueous extract. Six plants showed strong activity comparable to known antifungal agents. The plants that showed strong activity are worthy of further investigation in order to isolate and identify active compounds.
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1 - University of Lagos,, Botany, University Road, Akoka, Yaba, Lagos, Lagos, 23401-6754, Nigeria
2 - Delta State University, Botany, Abraka, Abraka, Delta State, Nigeria
Presentation Type: Oral Paper:Papers for Sections
Location: Union C/Hyatt
Date: Monday, July 9th, 2012
Time: 10:45 AM